With the growing availability of cancer patients receiving proton therapy comes the opportunity for more published studies on the patient outcomes. Several articles have been published regarding the initial treatment and long-term benefits of proton beam therapy.

• Rah JE, Oh DH, Kim JW, Kim DH, Suh TS, Ji YH, Shin DH, Lee SB, Kim DY, *Park SY. "Feasibility Study of Glass Dosimeter for in Vivo Measurement: Dosimetric Characterization and Clinical Application in Proton Beams", Int. J. Radiat. Oncol. Biol. Phys., 2012, in press

• Ghergherehchi M , Afarideh H, Kim YS, Park SY, Lee SB, Shin DH, Chai JS, Mu XJ, Lee BN. "Dosimetry and Microdosimetry of 10-220 MeV Proton Beams with CR-39 and their Verifications by Calculation of Reaction Cross Sections using Alice, TALYS and GENT4 Codes", Radiat. Meas., 2012, in press

• Kim SK, Lee SB, Yoo SH, Cho SK, Kim DW, Shin DH, Park SY, Kim CH, Lee SH. "The Quenching Effect, Signal to Noise and Contrast to Noise Ratios on Scintillator Screens for Proton Beam Dosimetry System", Jpn. J. Appl. Phys, 2012, in press

• Kim JS, Yoon MG, Kim SK, Shin DH, Lee SB, Lim YK, Kim DW, Park SY. "Three-dimensional Radiochromic Film Dosimetry of Proton Clinical Beams using a Gafchromic EBT2 Film Array", Radiat. Prot. Dosim., 2012, in press

• Yoo SH, Kim DH, Min BJ, Shin DH, Lee SB, Park SY, Kim JH, Hahn SJ. "Parameter Study on Radiation Therapy with Laser-Accelerated Electrons using a Sharp Density Transition Scheme", Jpn. J. Appl. Phys, 2012, in press

• Kim DW, Chung WK, Shin DO, Hwang UJ, Rah JE, Jung HJ, Lee SY, Shin DH, Yoon MG, Lee SB, Park SY. "Dose Response of Commercially Available Optically Stimulated Luminescent Detector, Al203:C for Megavoltage Photons and Electrons", Radiat. Prot. Dosim., 2012, in press

• Uwe Schneider, Antony Lomax, Peter Pemler, Jürgen Besserer, Dieter Ross, Norbert Lombriser, Barbara Kaser-Hotz, "'The Impact of IMRT and Proton Radiotherapy on Secondary Cancer Incidence", Strahlenther Onkol 2006;182:647–52. 

• C. S. Chung, N. Keating, T. Yock, N. Tarbell, "Comparative Analysis of Second Malignancy Risk in Patients Treated with Proton Therapy versus Conventional Photon Therapy", I. J. Radiation Oncology Biology Physics, Volume 72, Number 1, Supplement, 2008

• James A. Talcott, MD, SM; Carl Rossi, MD; William U. Shipley, MD; Jack A. Clark, PhD; Jerry D. Slater, MD; Andrzej Niemierko, PhD; Anthony L. Zietman, MD, "Patient-Reported Long-term Outcomes After Conventional and High-Dose Combined Proton and Photon Radiation for Early Prostate Cancer", JAMA, 2010; 303(11): 1046-1053.

• Anthony L. Zietman, Kyounghwa Bae, Jerry D. Slater, William U. Shipley, Jason A. Efstathiou, John J. Coen, David A. Bush, Margie Lunt, Daphna Y. Spiegel, Rafi Skowronski, B. Rodney Jabola, and Carl J. Rossi, "Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09", Journal of Clinical Oncology, Volume 28, Number 7, March 1, 2010.

• Minh Tam Truong, MD; Urmila R. Kamat, MPH; Norbert J. Liebsch, MD, PhD; William T. Curry, MD; Derrick T. Lin, MD; Fred G. Barker II, MD; Jay S. Loeffler, MD; Annie W. Chan, MD, "Proton Radiation Therapy for Primary Sphenoid Sinus Malignancies: Treatment Outcome and Prognostic Factors" Published online 17 June 2009 in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/hed.21092

• Tara A. Van De Water, M.SC.; Anthony J. Lomax, PhD.; Hendrik P. Bijl, MD, PhD; Marije E. De Jong, BA; Cornelis Schilstra, PhD; Eugen B. Hug, MD, and Johannes A. Langendijk, MD, PhD. "Potential Benefits of Scanned Intensity-Modulated Proton Therapy versus Advanced Photon Therapy with Regard to Sparing of the Salivary Glands in Oropharyngeal Cancer" Int. J. Radiation Oncology Biol. Phys., Vol. 79, No. 4, pp. 1216–1224, 2011.

• Bradford Hoppe, MD, MPH, Randal Henderson, MD, MBA, William M. Mendenhall, MD, Romaine C. Nichols, MD, Zuofeng Li, PhD, Nancy P. Mendenhall, MD, "Proton Therapy for Prostate Cancer". ONCOLOGY. Vol. 25 No. 7, June 8, 2011

• Samir Sejpal, MD; Ritsuko Komaki, MD; Anne Tsao, MD; Joe Y. Chang, MD, PhD; Zhongxing Liao, MD; Xiong Wei, MD; Pamela K. Allen, PhD; Charles Lu, MD; Michael Gillin, PhD, and James D Cox, MD, "Early Findings on Toxicity of Proton Beam Therapy With Concurrent Chemotherapy for Nonsmall Cell Lung Cancer" Cancer Month 00, 2011.

• Christine E. Hill-Kayser, Stefan Both and ZeligTochner, "Proton therapy: ever shifting sands and the opportunities and obligations within", Frontiers in Oncology, September 6, 2011

• Hwang UJ, Shin DH, Kim TH, Moon SH, Lim YK, Jeong HJ, Rah JE, Kim SS, Kim JY, Kim DY, Park SY, Cho KH. "The Effect of a Contrast Agent on Proton Beam Range in Radiotherapy Planning using Computed Tomography for Patients with Locoregionally Advanced Lung Cancer", Int. J. Radiat. Oncol. Biol. Phys., 2011, in press http://www.redjournal.org/article/S0360-3016(11)00326-9/abstract

• Jeong HJ, Rah JE, Hwang UJ, Yoo SH, Min BJ, Lee SY, Yoon MG, Shin DH, Park SY, Lee SB, Kim JY. "Estimation of the Secondary Cancer Risk Induced by Diagnostic Imaging Radiation during Proton Therapy", J. Radiol. Prot., Vol. 31, No. 4, pp. 477-87, 2011 http://www.ncbi.nlm.nih.gov/pubmed/22089084  

• Jang KW, Yoo WJ, Seo JK, Heo JY, Moon J, Park JY, Hwang EJ, Shin DH, Park SY, Cho HS, Lee BS. "Fabrication and Optimization of a Fiber-optic Radiation Sensor for Proton Beam Dosimetry", Nucl. Instr. and Meth. Phys. Res. A., Vol. 652, No. 1, pp. 841-45, 2011 http://www.sciencedirect.com/science/article/pii/S016890021001908X  

• Yoon MG, Shin DH, Kim JS, Kim JW, Kim DW, Park SY, Lee SB, Kim JY, Park HJ, Park BK, Shin SH. "Craniospinal Irradiation Techniques: A Dosimetric Comparison of Proton Beams with Standard and Advanced Photon Radiotherapy", Int. J. Radiat. Oncol. Biol. Phys., Vol. 81, No. 3, pp. 637-46, 2011 http://www.sciencedirect.com/science/article/pii/S0360301610008904  

• Lim YK, Hwang UJ, Shin DH, Kim DW, Kwak JW, Yoon MG, Lee DH, Lee SB, Lee SY, Park SY, Pyo HR. "Proton Range Uncertainty Due to Bone Cement Injected into the Vertebra in Radiation Therapy Planning", Med. Dosim., Vol. 36, No. 3, pp. 299-305, 2011 http://www.sciencedirect.com/science/article/pii/S0958394710000725  

• Park SA, Kwak JW, Yoon MG, Shin DH, Lee SB, Cho KH, Kang SK, Kim KJ, Bae HS, *Park SY. "Dose Verification of Proton Beam Therapy using the Gafchromic EBT Film", Radiat. Meas., Vol. 46, No. 8, pp. 717-21, 2011 www.sciencedirect.com/science/article/pii/S1350448711002800

• Kim DW, Lim YK, Ahn SH, Shin JW, Shin DH, Yoon MG, Lee SB, Kim DY, Park SY. "Prediction of Output Factor, Range, and Spread-out Bragg Peak for Proton Therapy", Med. Dosim., Vol. 36, No. 2, pp. 145-52, 2011 www.sciencedirect.com/science/article/pii/S0958394710000233

• Yoon MG, Cheong MH, Kim JS, Shin DH, Park SY, Lee SB. "Accuracy of an Automatic Patient Positioning System Based on the Correlation of Two Edge Images in Radiotherapy", J. Digit. Imaging, Vol. 24, No. 2, pp. 322-30, 2011 http://www.springerlink.com/content/wrm4614642l2p3x3/

• Kim SK, Min BJ, Yoon MG, Kim JS, Shin DH, Lee SB, Park SY, Cho SK, Kim DH. "Secondary Radiation Doses of Intensity-modulated Radiotherapy and Proton Beam Therapy in Patients with Lung and Liver Cancer", Radiother. Oncol., Vol. 98, No. 3, pp. 335-39, 2011 http://www.sciencedirect.com/science/article/pii/S0167814011000338

• Yoon MG, Ahn SH, Kim JS, Shin DH, Park SY, Lee SB, Shin KH, Cho KH. "Radiation-Induced Cancers from Modern Radiotherapy Techniques: IMRT vs. Proton Therapy", Int. J. Radiat. Oncol. Biol. Phys., Vol. 77, No. 5, pp. 1477-85, 2010 ( Selected Issue Highlights)

• Lim YK, Kwak JW, Kim DW, Shin DH, Yoon MG, Park SA, Kim JS, Ahn SH, Shin JW, Lee SB, Park SY, Pyo HR, Kim DY, Cho KH. "Microscopic Gold Particle-based Fiducial M arkers for Proton Therapy of Prostate Cancer", Int. J. Radiat. Oncol. Biol. Phys., Vol. 74, No. 5, pp. 1609-16, 2009 http://www.sciencedirect.com/science/article/pii/S0360301609005847

• Yoon MG, Shin DH, JW Kwak, SA Park, Lim YK, Kim DW, *Park SY, Lee SB, Shin KH, Kim TH, Cho KH. "Characteristics of movement-induced dose reduction in target volume: A comparison between photon and proton beam treatment", Med. Dosim., Vol. 34, No. 3, pp. 191-201, 2009 http://www.sciencedirect.com/science/article/pii/S0958394708001301

• Shin DH, Yoon MG, Kwak JW, Shin JW, Lee SB, Park SY, Park SA, Kim DY, Cho KH. "Secondary Neutron Doses for Several Proton Beam Configurations for Proton Therapy", Int. J. Radiat. Oncol. Biol. Phys., Vol. 74, No. 1, pp. 260-65, 2009

• Moon SH, Shin KH, Kim TH, Yoon MG, Park SA, Lee DH, Kim JW, Kim DW, Park SY, Cho KH. "Dosimetric comparison of four different external beam partial breast irradiation techniques: three-dimensional conformal radiotherapy, intensitymodulated radiotherapy, helical tomotherapy, and proton beam therapy", Radiother. Oncol., Vol. 90, No. 1, pp. 66-73, 2009 www.sciencedirect.com/science/article/pii/S0167814008005124

• Shin DH, Kim TH, *Park SY, Kwak JW, Moon SH, Yoon MG, Lee SB, Park SA, Shin KH, Kim DY, Cho KH, Park JW, Kim CM. "Influence of Lipiodol Agent on Proton Beam Range in Radiotherapy Planning using Computed Tomography for Hepatocellular Carcinoma", Int. J. Radiat. Oncol. Biol. Phys., Vol. 72, No. 3, pp. 687-94, 2008 http://www.sciencedirect.com/science/article/pii/S0360301608003209

• Yoon MG, Kim JS, Shin DH, Park SY, Lee SB, Kim DY, Kim TH, Shin KH, Cho KH. "Computerized tomography-based quality assurance tool for proton range compensators", Med. Phys., Vol. 35, No. 8, pp. 3511-17, 2008 http://online.medphys.org/resource/1/mphya6/v35/i8/p3511_s1?isAuthorized=no

• Yoon MG, Kim DW, Shin DH, *Park SY, Lee SB, Kim DY, Kim JY, Pyo HR, Cho KH. "Interfractional and Intrafractional Movement Induced Dose Reduction of Prostate Target Volume in Proton Beam Treatment", Int. J. Radiat. Oncol. Biol. Phys., Vol. 71, No. 4, pp. 1091-1102, 2008 http://www.sciencedirect.com/science/article/pii/S0360301607045968

• Concurrent high-dose proton therapy and chemotherapy is well tolerated, and the median survival time of 29.4 months is encouraging for unresectable stage III non-small-cell lung cancer. Cancer: October 15, 2011 http://onlinelibrary.wiley.com/doi/10.1002/cncr.26080/full

• In patients with mediastinal lymphomas, 3D proton beam therapy produced significantly lower doses to the lung, esophagus, heart, and coronary arteries than did the current conventional radiation therapy. These lower doses would be expected to reduce the risk of late toxicities in these major organs. Journal of Radiation Oncology Biology Physics: Vol 81: No. 1 (May 2010)

• Comparisons of organ-specific organ equivalent dose showed that the estimated secondary cancer risk using scattering mode in proton therapy is either significantly lower than the cases in IMRT treatment, or at least, does not exceed the risk induced by conventional IMRT treatment. Journal of Radiation Oncology Biology Physics: Vol 77: No. 5 (July 2009)

• Intensity-modulated proton therapy reduces the dose to normal tissue and allows individualized radiacal radiotherapy for extensive stage IIIB non-small-cell lung cancer. Journal of Radiation Oncology Biology Physics: Vol 77: No. 2 (April 2009) http://www.sciencedirect.com/science/article/pii/S0360301609006014  

• When considering exposure to primary and secondary radiation, proton therapy can reduce the risk of a secondary malignant neoplasm in prostate patients compared with contemporary intensity modulated radiation therapy (IMRT). Journal of Radiation Oncology Biology Physics: Vol 74: No. 2 (January 2009) http://www.sciencedirect.com/science/article/pii/S0360301609000340

• Superior dose localization properties of proton radiation therapy allow smaller volumes of normal tissues to be irradiated than is feasible with any photon technique. Initial clinical experience with proton radiation therapy in treatment of head and neck and skull base tumors is promising. Journal of Surgical Oncology 2008; 97: 697-700 http://onlinelibrary.wiley.com/doi/10.1002/jso.21013/abstract

• Proton treatment appears to reduce dose to norm al tissues significantly, even with dose escalation, compared with standard-dose photon therapy. Journal of Radiation Oncology Biology Physics: Vol 65: No. 4 (January 2006) http://www.sciencedirect.com/science/article/pii/S0360301606002458

• Proton Radiation Therapy for Primary Sphenoid Sinus Malignancies: Treatment Outcome and Prognostic Factors

• Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial

• Proton-beam therapy for olfactory neuroblastoma

• Proton Beam Radiation Therapy for Skull Base Adenoid Cystic Carcinoma

• Favorable Outcome of Combined Proton Radiotherapy and Chemotherapy for T4 Nasopharyngeal Carcinoma

• Protonradiation for treatment of cancer of the oropharynx: Earlyexperience at LomaLinda University Medical Center using a concomitant boost technique  

• Neuroendocrine Tumors of The Sinonasal Tract Results of a Prospective Study Incorporating Chemotherapy, Surgery, and Combined Proton-Photon Radiotherapy

• PotentialBenefits of ScannedIntensity-ModulatedProtonTherapy Versus Advanced Photon Therapy With Regard to Sparing of the Salivary Glands in Oropharyngeal Cancer